Monday, May 20, 2024

New material

Shinsegae International develops exosomes for skin regeneration

'Advanced Materials Interface' cover paper published

Shinsegae International's exosome research thesis has been featured on the cover of an international journal.


Shinsegae International announced that a thesis titled 'Skin regeneration efficacy of Euglena-derived exosome mimetics' was published as a cover paper in the February issue of 'Advanced Materials Interface'. Advanced Materials Interfaces is an international academic journal recognized for its authority in the field of materials science.


This thesis is the result of joint research by Shinsegae International Cosmetic Technology Innovation Center and Sungkyunkwan University. For two years, the company investigated the skin regeneration efficacy of exosomes applied with the latest biotechnology with Sungkyunkwan University Professor Kim Jin-woong's team.


Exosomes are a type of extracellular vesicles (EVs) excreted by cells. It is responsible for information exchange and signal transduction between cells.


Exosomes contain skin whitening and regenerating ingredients to provide skin improvement effects. Exosomes have a wide range of applications, including cosmetics, pharmaceuticals, and bio.


On the other hand, human-derived exosomes were difficult to commercialize. This is because the production yield is low and quality control such as contamination or deterioration of purity is difficult. There were many restrictions on using exosomes as a material in accordance with the cosmetic safety standards.


In response, Shinsegae International and Professor Kim Jin-woong's team developed a raw material to replace human-derived exosomes. We paid attention to the microalgae Euglena. Euglena has 59 nutrients such as vitamins and amino acids. It also contains beta glucan, which has excellent immunity enhancement and skin regeneration effects.


Shinsegae International separated and combined exosome-type substances from Euglena. This is because the cells are extruded through an ultra-fine filter. By optimizing the beta-glucan content and particle size, they developed non-animal exosome raw materials with excellent skin regeneration effects.


Euglena-derived exosomes can be cultured in large quantities. Compared to the existing beta glucan, the collagen production rate is improved by more than 20%. Promote skin cell proliferation and produce collagen.


Shinsegae International plans to introduce serial and vidivici products using Euglena-derived exosomes.


The results of this research have been applied for not only domestic patents but also international patents under the Patent Cooperation Treaty (PTC).


Kim Jun-oh, head of Shinsegae International's Technology Innovation Center, said, "In September of last year, at the International Cosmetic Society (IFSCC) held in London, England, we made an oral presentation on Euglena-derived exosome mimics. The world paid attention to the research results that expanded the scope of exosomes to microalgae. We will develop innovative technologies to secure differentiated materials.”